ENHANCED PROAPOPTOTIC EFFECTS OF WATER DISPERSED COMPLEXES OF 4-THIAZOLIDINONE-BASED CHEMOTHERAPEUTICS WITH A PEG-CONTAINING POLYMERIC NANOCARRIER

Abstract Aim To study whether water formulation of the complex of 4-thiazolidinone derivatives with a PEG-containing polymeric nanocarrier enhances their pro-apoptotic action towards rat glioma C6 cells.Methods Mechanisms of antineoplastic effects of 4-thiazolidinone derivatives were investigated in vitro with rat glioma C6 cells.Cell nativity, cel

BackgroundLiquid biopsies enable the detection of circulating tumor DNA (ctDNA).However, the clinical significance of KRAS-mutated ctDNA for pancreatic cancer has been inconsistent with respect to its prognostic and predictive potential.Methods and findingsA total of 422 blood samples were collected from 78 patients undergoing treatments for locali